Sirtuins (SIRTs) are enzymes critical for cellular health, metabolism, and longevity. Their levels decline with age, particularly after 35, contributing to tissue dysfunction and age-related diseases. However, research shows that exercise and natural compounds can reactivate these vital proteins.
- Exercise Benefits: Aerobic exercise increases SIRT1 and SIRT3 activity, reducing oxidative stress, enhancing mitochondrial health, and improving metabolic efficiency. Resistance training, while beneficial for muscle mass, has less consistent effects on sirtuins.
- Natural Activators: Compounds like resveratrol, pterostilbene, and ellagic acid found in foods and supplements can boost sirtuin activation. They are particularly effective in older adults where exercise alone may not suffice.
Combining regular aerobic exercise with a diet rich in sirtuin-activating substances or supplements can slow aging, reduce chronic disease risks, and enhance longevity.
