Recent research conducted by San Raffaele University has unveiled promising results on the effects of novel natural sirtuin activators, A5 and GAU. Sirtuins are NAD+-dependent enzymes known for their critical roles in cellular health, aging, and metabolic regulation.
- Aging Reversal: The compound A5 demonstrated the ability to reduce cellular aging markers in lab studies, hinting at its potential to counteract age-related deterioration.
- Improved Insulin Secretion: A5 significantly increased insulin secretion in both human pancreatic islets and mouse β-cells, positioning it as a candidate for diabetes treatment.
- Sirtuin Activation: A5 effectively activated nuclear sirtuins like SIRT1, a key player in metabolic homeostasis and longevity.
The research also highlights the potential of these compounds to improve β-cell function under diabetic conditions and protect cells from oxidative stress, offering a foundation for future therapies targeting aging and metabolic diseases.
