SIRT500’s formulation is grounded in a patent-protected composition (US11484541B2) that includes honokiol, pterostilbene, polydatin, ellagic acid, and essential nutrients like zinc, selenium, chromium, and vitamin B3. This blend is specifically designed to support the activation of sirtuins (SIRT1-7), crucial enzymes that play key roles in cellular repair, metabolism, stress resilience, and healthy aging.
Our approach draws on extensive research, including a collaboration with San Raffaele University of Rome. Their studies on our proprietary blend of sirtuin activators (referred to as A5) demonstrated that the right combination of polyphenols and micronutrients significantly enhances SIRT1 activity, reduces cellular senescence, and even supports insulin secretion in beta cells, linking sirtuin activation to both anti-aging and metabolic benefits [P1]. Additional investigations further validate the effects of these carefully chosen compounds:
A combination of polyphenols and micronutrients similar to those in SIRT500 inhibited influenza A and SARS-CoV-2 replication in vitro, reducing inflammation and enhancing cellular defenses. This suggests that sirtuin-supportive formulations can bolster cellular health and resilience [P2].
In a model of Parkinson’s disease, a polyphenol-micronutrient mix decreased neuroinflammation and oxidative stress while promoting dopaminergic neuron differentiation. By helping create a favorable environment for sirtuins, these ingredients may support brain health and neuronal integrity [P3].
Polyphenols have shown promise in reducing the risk factors associated with ischemic stroke by improving endothelial function, countering oxidative stress and inflammation, and aiding in metabolic control—processes in which sirtuins play a significant regulatory role [P4].
Research indicates that regular exercise enhances sirtuin activity, and when combined with sirtuin-activating nutrients, the effects may be even greater. This synergy suggests that incorporating SIRT500 into a healthy lifestyle can support metabolic balance, energy production, and cellular maintenance as we age [P5].
Achieving the same nutrient levels through daily diet alone would be impractical, requiring several kilograms of specific fruits or liters of certain juices. SIRT500’s slow-release formulation ensures sustained support for sirtuin activation. With polydatin (a potent resveratrol derivative) and synergistic micronutrients, it helps maintain robust NAD+ levels and reduces oxidative stress, essential conditions for sirtuins to operate effectively.
In essence, SIRT500 does more than just supply beneficial compounds; it creates the optimal biochemical environment for sirtuins to thrive. By integrating insights from our patent, partner-led research, and peer-reviewed studies, SIRT500 is designed to help you tap into the full potential of these longevity-related enzymes, supporting energy, metabolism, neurological health, and overall well-being.
Niacin is crucial for synthesizing NAD+ (Nicotinamide Adenine Dinucleotide), a coenzyme essential for energy metabolism and cellular function. High NAD+ levels are linked to enhanced sirtuin activation, supporting processes tied to health and longevity [55, 60, 61]. By converting into NAD+, niacin fuels sirtuins—proteins that regulate metabolism, DNA repair, and stress responses [56, 62]. Ensuring adequate niacin intake helps maintain healthy NAD+ levels, promoting metabolic balance and potentially reducing age-related health issues [55, 56, 63].
Niacin-derived NAD+ is critical for sirtuins to function efficiently in regulating metabolism and energy production [55, 60, 62].
By maintaining NAD+ for sirtuin activity, niacin supports DNA repair and helps cells better resist metabolic stress [55, 60, 62].
Enhancing sirtuin function through niacin can influence aging, improve mitochondrial function, and balance glucose and lipid metabolism [56, 63].
Zinc is a vital mineral for immune function, DNA synthesis, and cellular repair. While not a direct sirtuin activator, it fosters a healthy cellular environment that supports sirtuin pathways involved in metabolic regulation and longevity [64–66]. Zinc’s antioxidant properties also help protect cells from oxidative damage, indirectly maintaining the NAD+ levels needed for sirtuin activity [64, 65].
Zinc bolsters immune cells and reduces inflammation [64, 66].
By helping regulate glucose metabolism, zinc supports the conditions needed for sirtuins to thrive [65].
Zinc aids in DNA synthesis and repair, indirectly promoting efficient sirtuin-mediated maintenance of genomic stability [64, 65].
Selenium, known for its antioxidant properties, helps protect cells from oxidative damage. By reducing oxidative stress, selenium creates a favorable environment for sirtuins to function optimally [76]. This mineral is also essential for immune health and metabolic processes that maintain NAD+ levels.
Selenium-containing enzymes like glutathione peroxidase neutralise free radicals, supporting DNA repair and sirtuin function [76].
Adequate selenium intake improves insulin sensitivity and reduces inflammation, helping preserve the NAD+ pool for sirtuins [76].
Chromium is a trace mineral that regulates blood sugar and lipid metabolism, essential for stable energy production and indirectly supporting sirtuin activation [77–79]. By improving insulin efficiency and glucose utilization, chromium helps maintain metabolic balance and reduces oxidative stress.
Chromium enhances insulin sensitivity, ensuring stable glucose levels and preserving the NAD+ needed for sirtuin activity [79, 80].
Improved metabolic health supports better sirtuin function, aiding in energy homeostasis and stress resistance [78].
Chromium reduces oxidative stress, maintaining conditions that favour sirtuin-mediated cellular repair [77, 80].
Pomegranate extract delivers potent antioxidants that help reduce oxidative stress and inflammation [81–83]. By creating a more stable cellular environment, it indirectly supports sirtuin activation, enhancing processes like DNA repair and metabolic regulation.
Protect cells from oxidative damage, favouring conditions for sirtuin efficiency [82, 83].
May improve insulin sensitivity, supporting the NAD+ pool and sirtuin-dependent energy homeostasis [81, 83].
Reduces oxidative stress, aiding sirtuins in maintaining genomic integrity [82, 83].
Bilberry extract is rich in anthocyanosides that provide antioxidant and anti-inflammatory effects [84–86]. By reducing cellular damage and improving metabolic functions, bilberry creates a favorable environment for sirtuins to regulate critical pathways involved in healthy aging.
Neutralises free radicals, supporting the preservation of NAD+ and sirtuin activity [84, 86].
Enhances blood vessel integrity and glucose handling, indirectly aiding sirtuin-driven metabolic regulation [85].
Helps maintain genomic stability through reduced oxidative damage, enabling efficient sirtuin-mediated repair [84, 86].
Japanese knotweed is a source of resveratrol, a compound known to activate sirtuins, particularly SIRT1 [87–89]. By mimicking caloric restriction benefits, resveratrol supports metabolic balance, DNA repair, and other longevity-related processes.
Resveratrol enhances SIRT1 activity, improving DNA repair and metabolic efficiency [87, 89].
Helps stabilise blood sugar and lipids, maintaining conditions conducive to NAD+ production and sirtuin function [88, 89].
Associated with healthier aging, supporting sirtuin-driven resilience against stress and cellular damage [87, 89].
Magnolia bark extract contains honokiol and magnolol, compounds known for their antioxidant, anti-inflammatory, and stress-modulating properties [90–92]. By reducing metabolic stress and inflammation, magnolia indirectly supports sirtuin activity crucial for maintaining genomic stability and metabolic homeostasis.
Lowers pro-inflammatory markers, enabling sirtuins to function more effectively [90].
Helps balance cortisol-like effects, optimising metabolic pathways and energy levels [91, 92].
Protects cells from oxidative damage, preserving NAD+ and aiding sirtuin-mediated repair processes [90, 92].
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